What is refractory hypotension

Argipressin for effective therapy in septic shock

Argipressin - arginine vasopressin - can now be used in 26 EU countries as a new, effective therapy for septic shock.

Argipressin, also known as the posterior pituitary hormone, has now been approved as a new therapy for septic shock in 26 European countries. With its action, argipressin - also known as arginine vasopressin - belongs to the pharmacotherapeutic group vasopressin and analogues.

 

Argipressin - arginine vasopressin

Argipressin - arginine vasopressin, the posterior pituitary hormone or antidiuretic hormone - was modeled on the body's own posterior pituitary hormone vasopressin. The substance shows blood pressure-increasing and antidiuretic properties through contraction of the smooth muscles of the vascular system.

The active ingredient has been available in Germany since 2015 for use to stabilize the cardiovascular system in the event of septic shock. Catecholamine-refractory hypotension in a patient means that despite adequate volume therapy and the use of catecholamines, the mean arterial blood pressure cannot be stabilized to values ​​of 65-75 mmHg.

Argipressin was modeled on the body's own posterior pituitary hormone vasopressin. This so-called antidiuretic hormone regulates the body's water balance and leads to a reduction in urine excretion. In general, vasopressors are used to establish sufficient blood pressure and thus to supply the organs with sufficient oxygen.

In any case, argipressin, in early combination with the catecholamine norepinephrine, can stabilize the cardiovascular function very well. This also makes it possible to contain the toxic effects of high doses of norepinephrine - for example with damage such as arrhythmias, ischemia or the heart muscle cells. After all, this can also increase the chances of survival.

 

Treat septic shock

Every year 30 million people around the world suffer from septic shock, and around every fourth person dies from it. The term describes a state of shock caused by a generalized bacterial infection - sepsis.

Above all, the negative effects on the cardiovascular system are considerable and worsen the prognosis in the event of septic shock, since the endogenous vasodilator nitrogen monoxide (NO), by damaging the adrenal receptors, cancels the vasocontractive effect of the catecholamines in the long term.

In the case of septic shock, blood pressure drops, consciousness is clouded, and breathing and heart rates rise. A deterioration in macro and microcirculation can lead to disruption of the organ blood flow, organ damage and multiple organ failure.

The chances of survival in a septic shock depend essentially on how quickly the patient receives successful therapy for the infection as the cause of the sepsis. For this purpose, high-dose antibiotics are successfully used intravenously. In addition, the cardiovascular system is stabilized as quickly as possible in order to prevent organ damage.


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